The word unaffectionate is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 26
Highest Scoring Words With Friends™ Play In The Letters unaffectionate
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Seven Letter Word Alert: (32 words)
acetate, acetone, aconite, actuate, affiant, ancient, auction, canteen, catenin, caution, confine, confute, contain, content, cuneate, faction, fanatic, fiancee, fifteen, finance, infauna, nautica, neonate, nictate, noncute, nonfact, offence, outface, taffeta, tetanic, unction, uneaten