The word thriftlessly is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 21
Highest Scoring Words With Friends™ Play In The Letters thriftlessly
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Seven Letter Word Alert: (66 words)
fillers, fillets, filters, firstly, fishers, fishery, fitters, fleshly, flyless, freshly, heftily, hisself, hitters, leftist, lifters, lithely, litters, littler, lyrists, refills, relists, rellish, reshift, resifts, retills, retilts, rillets, selfish, sherifs, shifter, shrifts, shrills, shrilly, shyster, sifters, sitters, slither, slitter, stifler, stifles, stiller, stilter, strifes, stylers, stylets, stylier, stylise, stylish, stylist, testify, testily, theists, thirsts, thirsty, thistle, thistly, thrifts, thrifty, thrills, thrilly, thyself, tillers, tilters, tithers, trellis, trifles