The word substantiality is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Play In The Letters substantiality
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Seven Letter Word Alert: (34 words)
ability, abstain, abulias, abuttal, abyssal, analyst, assault, attains, aulists, autists, basalts, blatant, insults, intuits, lutists, nastily, nattily, saintly, statins, statist, stylist, sublist, sultana, sultans, sustain, tastily, titbits, titlist, tunably, unbaits, unlists, unsilty, untasty, utility