The word despondently is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 22
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (37 words)
denoted, denotes, densely, depends, deploys, deponed, depones, deposed, despond, doyenne, endnote, enstyle, eyespot, leptons, neotype, nestled, nondeep, nondyed, notedly, onestep, openest, peddles, pendent, pentode, pentose, pentyne, pestled, poteens, seedpod, spondee, steeply, sydnone, syntone, tendons, tensely, toddles, yodeled