"derangement" in the noun sense
1. derangement, mental unsoundness, unbalance
a state of mental disturbance and disorientation
2. upset, derangement, overthrow
the act of disturbing the mind or body
"his carelessness could have caused an ecological upset"
"she was unprepared for this sudden overthrow of their normal way of living"
Source: WordNet® (An amazing lexical database of English)
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