The word cottonseeds is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 16
Highest Scoring Words With Friends™ Plays In The Letters cottonseeds
:
Seven Letter Word Alert: (24 words)
cenotes, cestode, contest, cottons, denotes, densest, descent, detects, detents, detests, encodes, nosodes, octenes, osteons, scented, scooted, seconds, snooted, snotted, soonest, stenose, stented, stetson, tensest