The word megalomaniacal is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 28
Highest Scoring Words With Friends™ Play In The Letters megalomaniacal
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Seven Letter Word Alert: (37 words)
aclinal, aeolian, alcogel, almanac, amalgam, ammonia, ammonic, anaemia, anaemic, angelic, angioma, calling, calming, calomel, celling, coaling, coalman, coalmen, coinage, collage, congeal, galleon, geminal, genomic, glacial, gmelina, laminae, laminal, lemming, logical, magical, mailman, mailmen, malacia, manacle, manilla, micella