The word meaningfully is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 27
Highest Scoring Words With Friends™ Play In The Letters meaningfully
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Seven Letter Word Alert: (43 words)
agilely, allying, anglify, fallguy, falling, felling, finagle, finally, flagmen, flaming, flannel, flaying, fluming, fueling, funnily, gainful, gallium, geminal, gmelina, guanine, illfame, inanely, inflame, leafing, leaning, legumin, lineman, lingual, magnify, mangily, mauling, meaning, melanin, mulling, nullify, unagile, unalign, unleafy, unmanly, yealing, yeaning, yelling, yelming