The word unfamiliarity is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 24
Highest Scoring Words With Friends™ Play In The Letters
Seven Letter Word Alert: (26 words)
airlift, airmail, alumina, faintly, fantail, frailty, initial, laminar, lunaria, marital, martial, martian, martini, militar, militia, natural, niftily, nitrify, rufiyaa, ruminal, tailfan, tailfin, tramful, trayful, unfitly, unitary