The word unsettling is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 16
Highest Scoring Words With Friends™ Play In The Letters unsettling
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Seven Letter Word Alert: (27 words)
eluting, ensuing, glisten, gluiest, glutens, intents, lensing, letting, linnets, luniest, lusting, lutites, nesting, netting, nutlets, nutting, setting, singlet, tensing, tenting, testing, tingles, tunings, tunnels, ugliest, unsling, utensil