The word unreplaceable is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 26
Highest Scoring Words With Friends™ Play In The Letters unreplaceable
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Seven Letter Word Alert: (36 words)
balance, ballpen, banaler, bleeper, bluecap, bullpen, canulae, canular, capable, carbeen, carbene, cleaner, cleanup, crubeen, cueball, cuprene, curable, cureall, enabler, labeler, lacunae, nebulae, nebular, nuclear, paenula, parable, pleurae, pleural, reclean, relabel, repanel, replace, replane, rubella, unbrace, unclear