The word pointlessly is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 19
Highest Scoring Words With Friends™ Play In The Letters pointlessly
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Seven Letter Word Alert: (45 words)
enlists, epsilon, illness, ineptly, insoles, insteps, instyle, isotype, lentils, leptons, lesions, lintels, lioness, lionets, lipless, listens, nosiest, pinless, pistols, pistons, pitless, pleions, pollens, postils, silents, spinels, spinets, spinose, splines, splints, stepson, stollen, stonily, stylion, stylise, stylops, systole, tinsels, tipless, tonsils, topless, topline, toyless, tyloses, tylosis