The word irresponsibly is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 23
Highest Scoring Words With Friends™ Play In The Letters irresponsibly
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Seven Letter Word Alert: (65 words)
bipoles, boilers, bossier, bossily, boysier, brinier, broiler, byliner, bylines, byssine, elision, epsilon, insoles, inspire, ioniser, ionises, ironers, ironies, isospin, leprosy, lesions, lioness, lionise, liriope, lispers, lorries, lossier, noisier, noisily, ospreys, persons, pinless, pissier, pleions, preboil, prisons, probers, proline, pronely, pyrones, pyrrole, reboils, resoils, resorbs, resorps, respins, ribless, riboses, rinsers, risible, roilier, seniors, sensory, sirloin, slopers, snipers, snorers, soberly, sorrels, sorrily, spinels, spinier, spinose, splines, spoiler