The word irresponsible is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 21
Highest Scoring Words With Friends™ Play In The Letters irresponsible
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Seven Letter Word Alert: (86 words)
berries, bipoles, blesser, boilers, boreens, bossier, brinier, broiler, ebonies, elision, elopers, enrober, enrobes, epsilon, insoles, inspire, ioniser, ionises, ironers, ironies, isospin, lesions, lioness, lionise, liriope, lispers, lorries, lossier, noisier, openers, penises, peonies, persons, pieless, pinless, pioneer, pissier, pleions, poesies, preboil, presser, prisons, probers, proline, rebless, reboils, rebores, reliers, relines, reopens, repiles, repiner, repines, replier, replies, reposer, reposes, repress, reprise, reprobe, rerinse, resoils, resoles, resorbs, resorps, respins, respire, ribless, riboses, rinsers, risible, roilier, seniors, sirloin, slopers, snipers, snorers, soberer, soirees, sorrels, spinels, spinier, spinose, spleens, splines, spoiler