The word irreplaceable is playable in Words With Friends™, no blanks required. Because it is longer than 7 letters, you would have to play off an existing word or do it in several moves.
Words With Friends™ Letter Score: 24
Highest Scoring Words With Friends™ Play In The Letters irreplaceable
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Seven Letter Word Alert: (31 words)
airable, aircell, bleeper, braille, caliber, calibre, caliper, capable, cerebra, clearer, crabier, creeper, earlier, iceball, labeler, leerier, libeler, liberal, parable, parrell, piercer, pliable, prebill, prerace, railcar, rebrace, relabel, replace, replica, replier, reprice